Tofacitinib Intermediate (2R, 3R) -2,3-bis [(4-methylbenzoyl) oxy] succinic acid a me (3R, 4R) - N, 4-dimethyl-1- (phenylmethyl) -3-piperidine amine CAS No. 477600 -71-8

He mea koʻikoʻi kā mākou mau kikowaena tofacitinib i ka hana ʻana o tofacitinib, kahi lāʻau lapaʻau kaulana i hoʻohana ʻia no ka mālama ʻana i kekahi ʻano o ka maʻi arthritis.He kuleana koʻikoʻi kēia waena i ka hana ʻana o tofacitinib, e hāʻawi ana i kona pono a me ka maikaʻi.Via (2R,3R) -2,3-bis [(4-methylbenzoyl)oxy] succinic acid a me (3R,4R)-N,4-dimethyl-1-(phenylmethyl)- ʻO ka hui pololei o 3-piperidinamines, kā mākou hōʻoia ka huahana i ka synthesis o tofacitinib kiʻekiʻe kiʻekiʻe e hoʻokō a ʻoi aku i nā kūlana ʻoihana.

Hōʻike ka molecular formula a me ke kaumaha o kā mākou tofacitinib intermediate i kona maʻemaʻe a me kona ikaika, e lilo ia i mea hilinaʻi o ke kaʻina hana lāʻau.Me kāna mau mea i ana pono ʻia, e hōʻoiaʻiʻo kēia waena i ka kūlike a me ka pono o ka huahana hope, tofacitinib.Hāʻawi pū kāna mau mea molekala i ka paʻa holoʻokoʻa o tofacitinib a me ke ola paʻa, e hōʻoiaʻiʻo ana i ka maikaʻi a me ka hilinaʻi i ka wā lōʻihi.