Alpelisib Intermediate 4-Methyl-2- (1,1,1-trifluoro-2-dimethyl-2-ethyl) pyridine CAS NO.1378865-93-0

ʻO ka helu CAS 1378865-93-0, ʻO kā mākou 4-methyl-2- (1,1,1-trifluoro-2-dimethyl-2-ethyl) pyridine i hoʻopaʻa pono ʻia a hoʻāʻo ʻia e hoʻokō i nā kūlana maʻemaʻe kiʻekiʻe a me ka maikaʻi.He kuleana koʻikoʻi ia i ka synthesis o Alpelisib, kahi lāʻau lapaʻau i manaʻo ʻia no nā poʻe maʻi me ka maʻi maʻi umauma kiʻekiʻe a i ʻole nā ​​​​maʻi koko paʻa e mālama ana i nā mutations PIK3CA.

Ke lawelawe nei kēia kikowaena Alpelisib ma ke ʻano he hale kūkulu no Alpelisib synthesis, hiki ke hana i nā lāʻau lapaʻau i hōʻike i ka pono nui i nā hoʻokolohua lapaʻau.ʻO ka hana kemika pololei o kā mākou mau mea waena e hōʻoia i ko lākou kūpono a me ka pono i ka wā synthesis, e hāʻawi ana i ka maʻemaʻe kiʻekiʻe a me ka ikaika o ka huahana lāʻau lapaʻau hope loa.

ʻO ka 4-Methyl-2-(1,1,1-trifluoro-2-dimethyl-2-ethyl) pyridine intermediate he mea nui i ka synthesis chemical o Alpelisib a me kahi waena koʻikoʻi i ke kaʻina hana holoʻokoʻa.Me kāna ʻano molekala pololei a me ke kaumaha, ua hoʻolālā ʻia e hoʻokō i nā koi koʻikoʻi o ka hana lāʻau lapaʻau, e hōʻoia ana i ka kūpaʻa a me ka hilinaʻi i ka hana Alpelisib.